Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.

Abstract

Zoxazolamine paralysis, hexobarbital anesthesia and digitoxin convulsions were diminished in rats by 3 days of pretreatment with pregnenolone-16alpha-carbonitrile (PCN). Simultaneous injection of dl-ethionine did not block this effect of PCN. Dl-Ethionine decreased, while PCN or PCN + ethionene increased, zoxazolamine metabolism by the 9,000g supernatant fraction of the liver. Dl-ethionine neutralized the influence of PCN and phenobarbital on zoxazolamine metabolism in rats that were pretreated with PCN or phenobarbital for 1 day, and it inhibited the action of phenobarbital on hexobarbital anesthesia. PCN augmented the liver weight of animals given dl-ehtionine whereas dl-ethionine in itself did not. PCN produced SER proliferation in hepatocytes and dl-ethionine caused lipid accumulation, SER proliferation and myelin-figure formation. When administered conjointly, these compounds had an additive effect on the liver cell ultrastructure.

• Authors: B D Garg, P Kourounakis, B Tuchweber, S Szabo, K Kovacs
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 227 Issue 2 Pg. 283-93 (Jun 1977) ISSN: 0003-9780 [Print] Belgium
• PMID: 907413 (Publication Type: Journal Article)

Chemical References

• Pharmaceutical Preparations
• Pregnenolone Carbonitrile
• Zoxazolamine
• Hexobarbital
• Digitoxin
• Ethionine
• Phenobarbital

Topics

• Animals
• Digitoxin (pharmacology)
• Drug Interactions
• Ethionine (pharmacology)
• Female
• Hexobarbital (pharmacology)
• In Vitro Techniques
• Liver (drug effects, ultrastructure)
• Microscopy, Electron
• Paralysis (chemically induced, physiopathology)
• Pharmaceutical Preparations (metabolism)
• Phenobarbital (pharmacology)
• Pregnenolone Carbonitrile (pharmacology)
• Rats
• Seizures (chemically induced, physiopathology)
• Sleep (drug effects)
• Zoxazolamine (metabolism, pharmacology)