Abstract |
CD40 antigen, expressed on many cell types is involved in cell-cell interactions, with activated T cells expressing the CD40 ligand. In the skin, keratinocytes express CD40 which may play a role in amplifying inflammatory responses. We investigated the expression of this antigen in a series of epidermal tumors in correlation with T cell infiltrates. Our results indicate a-down-regulation or a drastic loss of CD40 antigen by tumor cells from basal cell carcinoma and squamous cell carcinoma and a moderate to discrete CD40 reactivity of keratinocyte from proliferative layers of benign viral-induced lesions. Endothelial cells, most infiltrating cells and a subpopulation of intraepidermal dendritic cells strongly expressed CD40, mainly in benign lesions, in which T cell-keratinocyte interactions may be observed, and were restricted to epithelial cells expressing CD40. The lack of CD40 expression by tumor cells might account for tumor escape mechanism from activated T cells expressing the CD40 ligand.
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Authors | J Viac, D Schmitt, A Claudy |
Journal | Anticancer research
(Anticancer Res)
1997 Jan-Feb
Vol. 17
Issue 1B
Pg. 569-72
ISSN: 0250-7005 [Print] Greece |
PMID | 9066581
(Publication Type: Journal Article)
|
Chemical References |
- Antigens, Neoplasm
- CD40 Antigens
|
Topics |
- Antigens, Neoplasm
(analysis)
- CD40 Antigens
(analysis)
- Carcinoma, Basal Cell
(immunology)
- Carcinoma, Squamous Cell
(immunology)
- Condylomata Acuminata
(immunology)
- Humans
- Skin Neoplasms
(immunology)
- Warts
(immunology)
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