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CD40 expression in epidermal tumors.

Abstract
CD40 antigen, expressed on many cell types is involved in cell-cell interactions, with activated T cells expressing the CD40 ligand. In the skin, keratinocytes express CD40 which may play a role in amplifying inflammatory responses. We investigated the expression of this antigen in a series of epidermal tumors in correlation with T cell infiltrates. Our results indicate a-down-regulation or a drastic loss of CD40 antigen by tumor cells from basal cell carcinoma and squamous cell carcinoma and a moderate to discrete CD40 reactivity of keratinocyte from proliferative layers of benign viral-induced lesions. Endothelial cells, most infiltrating cells and a subpopulation of intraepidermal dendritic cells strongly expressed CD40, mainly in benign lesions, in which T cell-keratinocyte interactions may be observed, and were restricted to epithelial cells expressing CD40. The lack of CD40 expression by tumor cells might account for tumor escape mechanism from activated T cells expressing the CD40 ligand.
AuthorsJ Viac, D Schmitt, A Claudy
JournalAnticancer research (Anticancer Res) 1997 Jan-Feb Vol. 17 Issue 1B Pg. 569-72 ISSN: 0250-7005 [Print] Greece
PMID9066581 (Publication Type: Journal Article)
Chemical References
  • Antigens, Neoplasm
  • CD40 Antigens
Topics
  • Antigens, Neoplasm (analysis)
  • CD40 Antigens (analysis)
  • Carcinoma, Basal Cell (immunology)
  • Carcinoma, Squamous Cell (immunology)
  • Condylomata Acuminata (immunology)
  • Humans
  • Skin Neoplasms (immunology)
  • Warts (immunology)

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