Abstract | BACKGROUND: 13C-Hiolein is a randomly 13C-labeled mixture of long chain triglycerides synthesized by algae. METHODS: RESULTS: Administration of 1.5 mg/kg 13-C-Hiolein together with a physiological mixed meal (1.5 g/kg rice cookies, containing 25% fat and 37% starch) resulted in significantly higher breath 13CO2/12CO2 ratios in controls than in cystic fibrosis children (maximal delta over baseline responses (DOBmax) 39.2 +/- 18.1% vs. 13.1 +/-13.9%; p < 0.001). With pancreatin, DOBmax in the cystic fibrosis patients responses returned completely to normal (39.2 +/- 29.2% DOBmax). A breath hydrogen increase indicating the malassimilation of starch was noticed in one patient with severe pancreatic insufficiency only. CONCLUSION: In contrast to fecal fat analysis, the 13C-Hiolein breath test reflects postprandial fat assimilation immediately after a given, labeled meal. Monitoring the oxidative fate of physiological test meal with a stable isotope breath test, this study shows that fat assimilation in cystic fibrosis patients can be normalized with high dose pancreatin.
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Authors | B Braden, H Picard, W F Caspary, H G Posselt, B Lembcke |
Journal | Zeitschrift fur Gastroenterologie
(Z Gastroenterol)
Vol. 35
Issue 2
Pg. 123-9
(Feb 1997)
ISSN: 0044-2771 [Print] Germany |
PMID | 9066102
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbon Radioisotopes
- Dietary Fats
- Triglycerides
- Pancreatin
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Topics |
- Adolescent
- Breath Tests
- Carbon Radioisotopes
- Child
- Cross-Over Studies
- Cystic Fibrosis
(physiopathology, therapy)
- Dietary Fats
(metabolism)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Intestinal Absorption
(drug effects, physiology)
- Male
- Pancreatin
(administration & dosage)
- Triglycerides
(metabolism)
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