[Stomach adenocarcinoma induction in rats by the combined administration of N-methyl-N-nitroso-N'-nitroguanidine precursors].

Abstract

N-methyl-N'-nitroguanidine and sodium nitrite were administered as drinking water to non-inbred male rats at the level of Img/ml for over two years. Gastric adenocarcinomas were produced in 43.7% of rats surviving for 15.5 months when the first tumor was noticed. Gastric mucous membrane of other rats had morphological changes analogous to those induced by N-methyl-N-nitoroso-N'-nitroguanidine (MNNG). The results obtained indicate endogenous synthesis of MNNG from precursors in the stomach of rats.

• Authors: L A Kartasheva
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 23 Issue 8 Pg. 54-7 ( 1977) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Induktsiia adenokartsinom zheludka u krys pri sovmestnom vvedenii predshestvennikov N-metil-N-nitrozo-N'-nitroguanidina.
• PMID: 906407 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nitrites
• Methylnitronitrosoguanidine
• Sodium

Topics

• Adenocarcinoma (chemically induced)
• Administration, Oral
• Animals
• Male
• Methylnitronitrosoguanidine
• Neoplasms, Experimental (chemically induced)
• Nitrites
• Rats
• Sodium
• Stomach Neoplasms (chemically induced)
• Time Factors