Managing recurrent vulvovaginal candidiasis. Intermittent prevention with itraconazole.

Abstract

OBJECTIVE:

To evaluate the efficacy of one-day, intermittent, monthly prophylaxis with 400 mg itraconazole in the management of recurrent vulvovaginal candidiasis.

STUDY DESIGN:

In a randomized trial, 57 patients and 57 controls with recurrent vulvovaginal candidiasis were assigned either to receive one-day monthly itraconazole prophylaxis for six months or no treatment. Clinical and mycologic evaluations were carried out 3, 6 and 12 months after enrollment.

RESULTS:

During the first six months of follow-up, the rate of symptomatic recurrences was 36.4% (20/55) among the treated women and 64.2% (34/53) in the controls. The mean time +/- SEM to symptomatic recurrence was 149 +/- 6 days among patients receiving prophylaxis and 120 +/- 6 days in the controls (P = .003 by log-rank test). These differences disappeared almost completely after the cessation of intermittent prophylaxis. In fact, the proportion of patients still asymptomatic after one year of follow-up was 38.9% (21/54) among treated women and 28.8% (15/53) in the controls (P = .83 by Fisher's exact test).

CONCLUSION:

One-day monthly, intermittent itraconazole prophylaxis reduced the rate of recurrence in patients with recurrent vulvovaginal candidiasis, but the beneficial effect of itraconazole was lost within a few months after cessation of prophylaxis.

• Authors: A Spinillo, L Colonna, G Piazzi, F Baltaro, A Monaco, A Ferrari
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 42 Issue 2 Pg. 83-7 (Feb 1997) ISSN: 0024-7758 [Print] United States
• PMID: 9058342 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Itraconazole

Topics

• Adult
• Antifungal Agents (administration & dosage, therapeutic use)
• Candidiasis, Vulvovaginal (drug therapy, prevention & control)
• Female
• Humans
• Itraconazole (administration & dosage, therapeutic use)
• Recurrence