[Serologic-nephelometric method for the detection of allergic reactions to small-molecular drugs using polystyrene sodium particles instead of soluble polystyrene sulfonate sodium as pharmaceutic aids].

Abstract

The previously developed two-step method using soluble polystyrene sulfonate-Na for the detection of allergic reactions to small molecular drugs has been replaced by a one-step method using particles of the same substance. The new method is simpler to perform. Particulate polystyrene sulfonate is commercially available. The drug is added in increasing concentrations to diluted serum samples and the light scattering is measured with a highly sensitive nephelometer. Both the specific serum factor in the patient's serum (globulins) and the non-specific factor contained in most fresh human sera are particularly labile.

• Authors: R Hoigné, S Rink, R Patrizzi, J Spiess, C Bavaud, M Spring, L Waefler Tschudi
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 107 Issue 32 Pg. 1125-33 (Aug 13 1977) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Serologisch-nephelometrische Methode zum Nachweis von Allergien gegen klein-molekulare Medikamente: die Benützung von Polystyrolsulfonat-Natrium-Partikeln anstelle von löslichem Polystyrolsulfonat-Natrium als Hilfssubstanz.
• PMID: 905808 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigen-Antibody Complex
• Polystyrenes

Topics

• Antibody Formation (drug effects)
• Antigen-Antibody Complex
• Drug Hypersensitivity (diagnosis)
• Humans
• Lymphocyte Activation (drug effects)
• Molecular Weight
• Particle Size
• Pharmacology
• Polystyrenes