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Determination of indole and 3-methylindole in plasma and rumen fluid from cattle with fog fever or after L-tryptophan administration.

Abstract
A modified gas liquid chromatography method has been developed to analyse the concentrations of indole and 3-methylindole in samples of plasma and rumen fluid from four cows with fog fever together with four control animals and from two cattle given L-tryptophan orally. Satisfactory recoveries of the metabolites were obtained in test samples examined by the gas liquid chromatography procedure and increased levels were found in rumen fluid after tryptophan administration. Absence of abnormal concentrations of the toxic metabolite 3-methylindole in samples from field cases of fog fever was not considered to rule out the metabolite as a possible cause of the disease in view of the rapid restoration of 3-methylindole to normal levels by the second day after loading with L-tryptophan.
AuthorsA Mackenzie, R K Heaney, G R Fenwick
JournalResearch in veterinary science (Res Vet Sci) Vol. 23 Issue 1 Pg. 47-50 (Jul 1977) ISSN: 0034-5288 [Print] England
PMID905654 (Publication Type: Journal Article)
Chemical References
  • Indoles
  • Tryptophan
  • Skatole
Topics
  • Animals
  • Cattle
  • Cattle Diseases (metabolism)
  • Chromatography, Gas
  • Female
  • Indoles (blood, metabolism)
  • Male
  • Pneumonia, Atypical Interstitial, of Cattle (metabolism)
  • Rumen (metabolism)
  • Skatole (blood, metabolism)
  • Tryptophan (metabolism)

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