Continued studies on the adjuvancy effect of natural and synthetic double-stranded RNA preparations with inactivated Newcastle disease vaccines in fowls.

Abstract

The adjuvant effect of the natural ds-RNA, BRL 5907, with inactivated Newcastle disease vaccines was confirmed using different oil-based formulations and could be given either as single injections or separately at adjacent sites. A minimum dose level of 0-04 mg BRL 5907 per bird was required for a significant enhancement of antibody levels following vaccination. While the synthetic ds-RNA Poly IC gave a similar response to that observed with BRL 5907, no significant effects could be detected with two other natural ds-RNA materials.

• Authors: D J Knight, J W Leiper, R E Gough, W H Allan
• Journal: Research in veterinary science (Res Vet Sci) Vol. 23 Issue 1 Pg. 38-42 (Jul 1977) ISSN: 0034-5288 [Print] England
• PMID: 905652 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Oils
• Polynucleotides
• Viral Vaccines
• Poly A
• Poly U
• RNA
• Poly I-C

Topics

• Adjuvants, Immunologic (administration & dosage)
• Animals
• Chickens (immunology)
• Hemagglutination Tests
• Newcastle Disease (prevention & control)
• Newcastle disease virus (immunology)
• Oils (administration & dosage)
• Poly A (administration & dosage)
• Poly I-C (administration & dosage)
• Poly U (administration & dosage)
• Polynucleotides (administration & dosage)
• RNA (administration & dosage)
• Viral Vaccines (administration & dosage)