Pharmacokinetics of sulphadimethoxine in cattle.

Abstract

Four healthy Angus steers received a single rapid intravenous injection of sulphadimethoxine at a dose of approximately 55 mg/kg. The elimination half-life determined from plasma concentration-time data was approximately 12-5 h, and the volume of distribution was 31-0 per cent of body weight. Animals also received sulphadimethoxine intravenously or orally at a loading dose of approximately 55 mg/kg, followed by sustaining oral doses of approximately 27-5 mg/kg at 24, 48 and 72 h. It was demonstrated that oral maintenance doses served to sustain sulphonamide plasma concentrations achieved with the loading dose.

• Authors: H G Boxenbaum, J Fellig, L J Hanson, W E Snyder, S A Kaplan
• Journal: Research in veterinary science (Res Vet Sci) Vol. 23 Issue 1 Pg. 24-8 (Jul 1977) ISSN: 0034-5288 [Print] England
• PMID: 905649 (Publication Type: Journal Article)

Chemical References

• Sulfadimethoxine

Topics

• Administration, Oral
• Animals
• Cattle (metabolism)
• Injections, Intravenous
• Intestinal Absorption
• Male
• Sulfadimethoxine (administration & dosage, blood, metabolism)