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Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.

Abstract
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
AuthorsT Luna, R Mazzolla, G Romanò, E Blasi
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 41 Issue 3 Pg. 706-8 (Mar 1997) ISSN: 0066-4804 [Print] United States
PMID9056019 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Polyenes
  • partricin
  • Amphotericin B
Topics
  • Amphotericin B (administration & dosage, therapeutic use)
  • Animals
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Brain (microbiology)
  • Brain Diseases (drug therapy, microbiology)
  • Colony Count, Microbial
  • Dose-Response Relationship, Drug
  • Female
  • Meningitis, Cryptococcal (drug therapy, microbiology)
  • Mice
  • Polyenes (administration & dosage, therapeutic use)

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