Abstract | BACKGROUND: METHODS: RESULTS: Model biles remained optically clear during the initial 48 h of incubation. Then, biles containing THDC and TUDC, but not those with TC and TCDC, became progressively turbid until, after several days, a white precipitate surrounded the residual stone. Abundant liquid crytalline droplets were observed at polarizing microscopy in biles containing TUDC and THDC. Gallstone dissolution was closely related to cholesterol solubilization and decreased in the order TCDC > THDC > or = TC > TUDC, being highest at pH 8. At the physiologic pH of 7 THDC was more litholythic than TC. CONCLUSIONS:
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Authors | M Angelico, L Mogavero, L Baiocchi, A Nistri, C Gandin |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 30
Issue 12
Pg. 1178-85
(Dec 1995)
ISSN: 0036-5521 [Print] England |
PMID | 9053971
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Cholagogues and Choleretics
- Drug Combinations
- Phosphatidylcholines
- taurohyodeoxycholic acid
- Taurochenodeoxycholic Acid
- Taurodeoxycholic Acid
- ursodoxicoltaurine
- Cholesterol
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Topics |
- Cholagogues and Choleretics
(chemistry, therapeutic use)
- Cholelithiasis
(chemistry, drug therapy)
- Cholesterol
(analysis)
- Drug Combinations
- Drug Evaluation, Preclinical
- Humans
- Hydrogen-Ion Concentration
- Phosphatidylcholines
(therapeutic use)
- Taurochenodeoxycholic Acid
(chemistry, therapeutic use)
- Taurodeoxycholic Acid
(analogs & derivatives, chemistry, therapeutic use)
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