Role of catechol estrogens in activation of lordosis in female rats and guinea pigs.

Abstract

In a variety of experiments, we tested the effectiveness of the 2-hydroxylated estrogen in facilitating sexual receptivity. A single injection of 2-hydroxy-estradiol-17beta (2-OHE2) to ovariectomized rats or 2-hydroxy-estrone (2-OHE1) to ovariectomized guinea pigs was ineffective in priming animals for facilitation of sexual receptivity even when a subsequent injection of progesterone was administered. The only facilitatory effect of catechol estrogens on lordosis that was demonstrated in this study occurred when 2-OHE2 was injected in combination with E2 and a subsequent injection of progesterone was given to rats. These results suggest a cooperatively between catechol estrogen and E2, but they also indicate that catechol estrogens, by themselves, do not play a crucial role in mediating sexual receptivity in rodents.

• Authors: B L Marrone, J F Rodriguez-Sierra, H H Feder
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 7 Issue 1 Pg. 13-7 (Jul 1977) ISSN: 0091-3057 [Print] United States
• PMID: 905327 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Catechols
• Estrogens
• Estrone
• Progesterone
• Estradiol

Topics

• Animals
• Castration
• Catechols (pharmacology)
• Estradiol (analogs & derivatives, pharmacology)
• Estrogens (pharmacology)
• Estrone (pharmacology)
• Female
• Guinea Pigs
• Progesterone (pharmacology)
• Rats
• Sexual Behavior, Animal (drug effects)
• Time Factors