Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women.

Abstract

The role of plasma lipoproteins in the development of non-insulin-dependent diabetes mellitus (NIDDM) was studied in 787 non-diabetic (2-h glucose < 11.1 mmol/l) Pima Indians (265 men and 522 women). Subjects were followed for a mean of 9.8 (range: 1.8-16.4) years, during which 261 (76 men and 185 women) developed NIDDM. In men and women, very-low-density lipoprotein (VLDL) cholesterol, VLDL triglyceride, low-density lipoprotein triglyceride and total triglyceride, controlled for age, predicted NIDDM (P < 0.01 for each). These effects diminished when controlled for age, sex, body mass index, systolic blood pressure and 2-h glucose. However, high-density lipoprotein (HDL) cholesterol, controlled for age, body mass index, systolic blood pressure and 2-h glucose, was a significant protective factor for NIDDM in women (hazard rate ratio (HRR) = 0.35, 95% CI (0.23-0.54), P < 0.001, 90th compared with 10th percentile) but not in men (HRR = 1.04, 95% CI (0.53-2.05), P = 0.915). This association remained significant in women when controlled for fasting or 2-h plasma insulin concentrations, other estimates of insulin resistance or alcohol consumption. The protective effect of HDL cholesterol was similar among women with normal (2-h glucose < 7.8 mmol/1) or impaired (7.8 mmol/l < or = 2-h glucose < 11.1 mmol/l) glucose tolerance at baseline. These results indicate that lipoprotein disorders are an early accompaniment of the abnormalities that lead to NIDDM.

• Authors: A Fagot-Campagna, K M Narayan, R L Hanson, G Imperatore, B V Howard, R G Nelson, D J Pettitt, W C Knowler
• Journal: Atherosclerosis (Atherosclerosis) Vol. 128 Issue 1 Pg. 113-9 (Jan 03 1997) ISSN: 0021-9150 [Print] Ireland
• PMID: 9051204 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Cholesterol, HDL
• Cholesterol, VLDL
• Insulin
• Lipoproteins
• Lipoproteins, LDL
• Lipoproteins, VLDL
• Triglycerides
• low density lipoprotein triglyceride
• very low density lipoprotein triglyceride

Topics

• Adult
• Arizona
• Blood Glucose (analysis)
• Blood Pressure
• Body Mass Index
• Cholesterol, HDL (blood)
• Cholesterol, VLDL (blood)
• Diabetes Mellitus, Type 2 (blood, ethnology)
• Female
• Humans
• Indians, North American
• Insulin (blood)
• Insulin Resistance
• Lipoproteins (blood)
• Lipoproteins, LDL (blood)
• Lipoproteins, VLDL (blood)
• Male
• Proportional Hazards Models
• Risk Factors
• Triglycerides (blood)