Negative association of schizophrenia with HLA DQB1*0602: evidence from a second African-American cohort.

Abstract

The authors attempted a replication of an earlier study of African-Americans, in which they detected a negative association of schizophrenia with HLA DQB1*0602. Patients with schizophrenia (n = 75, DSM-III-R criteria) and screened adult controls of African-American ethnicity (n = 66) were genotyped with respect to HLA DQB1*0602 using a combination of two polymerase chain reaction (PCR) based assays: amplification with sequence specific primers and a dot blot assay. A significant negative association with HLA DQB1 was not noted overall, but was present among women (female patients vs. female controls: odds ratio, OR = 0.42, 95% confidence intervals, CI = 0.32, 0.55). Reanalysis of the earlier study also revealed a gender related association. When the present and earlier samples from both genders were combined, the association persisted (OR 0.48; 95% CI: 0.12, 0.52). The present findings support and association between schizophrenia and the HLA DQB1 gene locus among African-Americans.

• Authors: V L Nimgaonkar, W A Rudert, X Zhang, M Trucco, R Ganguli
• Journal: Schizophrenia research (Schizophr Res) Vol. 23 Issue 1 Pg. 81-6 (Jan 17 1997) ISSN: 0920-9964 [Print] Netherlands
• PMID: 9050131 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQB1 antigen

Topics

• Adult
• Black People (genetics)
• Cohort Studies
• Female
• Genotype
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains
• Humans
• Male
• Middle Aged
• Pennsylvania
• Polymerase Chain Reaction
• Psychiatric Status Rating Scales
• Reproducibility of Results
• Schizophrenia (genetics)
• Schizophrenic Psychology
• Sex Factors