Abstract |
The efficiency of racemic-2,3-dimercaptosuccinic acid (rac- DMSA) compared with meso-2,3-dimercaptosuccinic acid (meso- DMSA) in mobilizing inorganic mercury was evaluated in female rats. Chelators were administered orally at a dose of 0.5, 1.0 or 2.0 mmol kg-1 on four consecutive days, 5 days after a single intraperitoneal 203Hg injection (with 0.5 mg HgCl2 kg-1). Both chelators reduced 203Hg retention in whole body and kidney and at higher doses also in the liver. Racemic- DMSA was more efficient at lower dose levels and equal to meso- DMSA at the highest dose level. Kidney retention decreased after rac- DMSA to 27, 10 and 10% of controls and after meso- DMSA to 68, 39 and 10% of control values at the 0.5, 1.0 and 2.0 mmol kg-1 dose level, respectively. Since meso- DMSA is already approved for human use, its stereoisomeric form, rac- DMSA, deserves further attention for treatment of mercury poisoning.
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Authors | K Kostial, N Restek-Samarzija, M Blanusa, M Piasek, L Prester, M M Jones, P K Singh |
Journal | Journal of applied toxicology : JAT
(J Appl Toxicol)
1997 Jan-Feb
Vol. 17
Issue 1
Pg. 71-4
ISSN: 0260-437X [Print] England |
PMID | 9048230
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Chelating Agents
- Succimer
- Mercury
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Topics |
- Administration, Oral
- Animals
- Body Burden
- Chelating Agents
(pharmacology)
- Female
- Kidney
(drug effects, metabolism)
- Mercury
(metabolism)
- Rats
- Rats, Wistar
- Stereoisomerism
- Succimer
(pharmacology)
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