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Racemic-2,3-dimercaptosuccinic acid for inorganic mercury mobilization in rats.

Abstract
The efficiency of racemic-2,3-dimercaptosuccinic acid (rac-DMSA) compared with meso-2,3-dimercaptosuccinic acid (meso-DMSA) in mobilizing inorganic mercury was evaluated in female rats. Chelators were administered orally at a dose of 0.5, 1.0 or 2.0 mmol kg-1 on four consecutive days, 5 days after a single intraperitoneal 203Hg injection (with 0.5 mg HgCl2 kg-1). Both chelators reduced 203Hg retention in whole body and kidney and at higher doses also in the liver. Racemic-DMSA was more efficient at lower dose levels and equal to meso-DMSA at the highest dose level. Kidney retention decreased after rac-DMSA to 27, 10 and 10% of controls and after meso-DMSA to 68, 39 and 10% of control values at the 0.5, 1.0 and 2.0 mmol kg-1 dose level, respectively. Since meso-DMSA is already approved for human use, its stereoisomeric form, rac-DMSA, deserves further attention for treatment of mercury poisoning.
AuthorsK Kostial, N Restek-Samarzija, M Blanusa, M Piasek, L Prester, M M Jones, P K Singh
JournalJournal of applied toxicology : JAT (J Appl Toxicol) 1997 Jan-Feb Vol. 17 Issue 1 Pg. 71-4 ISSN: 0260-437X [Print] England
PMID9048230 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Chelating Agents
  • Succimer
  • Mercury
Topics
  • Administration, Oral
  • Animals
  • Body Burden
  • Chelating Agents (pharmacology)
  • Female
  • Kidney (drug effects, metabolism)
  • Mercury (metabolism)
  • Rats
  • Rats, Wistar
  • Stereoisomerism
  • Succimer (pharmacology)

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