A new substance effective against transplantable tumors in vivo: L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide.

Abstract

It is shown that L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide-hydro-bromide possesses strong (50-100%) inhibitory effect in vivo against myeloma P-8, carcinosarcoma Walker, lymphosarcoma Pliss, sarcoma Yoshida, sarcoma Jensen and sarcoma 180 in doses 5-12 mg/kg/day. No suppression of the growth of Ehrlich ascites tumor was observed. The acute toxicity (LD50) of this substance on mice and rats is 71 mg/kg and 47 mg/kg respectively.

• Authors: E V Golovinsky, B V Alexiev, A V Spassov, S B Stoev, E A Emanuilov, I I Angelov, L S Maneva, T S Stoychev
• Journal: Neoplasma (Neoplasma) Vol. 24 Issue 4 Pg. 401-4 ( 1977) ISSN: 0028-2685 [Print] Slovakia
• PMID: 904741 (Publication Type: Journal Article)

Chemical References

• Nitrogen Mustard Compounds
• Cystine

Topics

• Alkylation
• Animals
• Carcinoma, Ehrlich Tumor (drug therapy)
• Cats
• Cystine (analogs & derivatives, therapeutic use)
• Lethal Dose 50
• Mice
• Mice, Inbred BALB C
• Multiple Myeloma (drug therapy)
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Nitrogen Mustard Compounds (therapeutic use)
• Rats
• Sarcoma, Experimental (drug therapy)
• Transplantation, Homologous