[Treatment of primary hyperlipoproteinemia type IIb and IV. Comparison of the lipid lowering effect of phenformin, clofibrate, and a combination of both (author's transl)].
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| Abstract |
22 outpatients with primary hyperlipoproteinemia type IIb and IV were treated in periods of eight weeks as follows: placebo; 0,15 g phenformin/day; 0,15 g phenformin + 1,5 g clofibrate/day; 1,5 g clofibrate/day; placebo. Compared to the first placeboperiode the serumtriglycerides were significantly lowered by phenformin (about 26%), by the combined treatment with phenformin + clofibrate (60%) and by clofibrate (51%) after eight weeks of treatment. The serumcholesterol was significantly lowered by phenformin (10%) and by the combined treatment with phenformin and clofibrate (14%), but not significantly by clofibrate (8%). After eight weeks of treatment with phenformin alone or in combination with clofibrate the body weight decreased significantly (1,9% or 1,4%). These changes in body weight were not related to changes in blood lipids. In conclusion, the combined treatment with 0,15 g clofibrate/day was more effective in lowering increased serum lipids than the treatment with phenformin or clofibrate alone.
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| Authors | T Koschinsky, P Lenhard, F A Gries, K H Vogelberg, G Wolfram, P D Lang, J Vollmar |
| Journal | Medizinische Klinik (Med Klin) Vol. 72 Issue 38 Pg. 1537-43 (Sep 23 1977) ISSN: 0025-8458 [Print] Germany |
| Vernacular Title | Therapie primärer Hyperlipoproteinämien Typ IIb und IV. Vergleich der serumlipidsenkenden Wirkung von Phenformin, Clofibrat und der Kombination von Phenformin mit Clofibrat. |
| PMID | 904549 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article) |
| Chemical References |
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