[The validation of the possible use of monosugars and 6-azacytidine for the elimination of Mollicutes associated with HIV/AIDS from the human urogenital tract].

A search for the methods new in principle which should block and eliminate AIDS-associated mycoplasmas was carried out. This work was conducted in two ways: 1) inhibition of vital activity of Mycoplasma fermentans PG-18 and Acholeplasma laidlawii PG-8 by 6-azacytidine; 2) establishment of carbohydrate composition of receptors for these mycoplasmas aimed at the competitive elimination of these microorganisms from urogenital tract of a man using carbohydrates. It is established that a 50%-inhibiting concentration of 6-azacytidine was 23.4 micrograms/ml for M. fermentans PG-18 and 62.5 micrograms/ml for A. laidlawii PG-8. alpha-D-glucose and N-acetylneuramine acid are two terminal carbohydrates that can serve as receptors for M. fermentans on human mucous membranes while D-mannose and N-acetyl-D-glucosamine for A. laidlawii PG-8. alpha-D-glucose in concentration 75 mM and N-acetylneuramine acid in concentration 150 mM competitively inhibit reception of M. fermentans on mucosae, while D-mannose in concentration 150 mM and N-acetyl-D-glucosamine in concentration 75 mM are antireceptor substances for A. laidlawii.
AuthorsI H Skrypal', A M Onyshchenko, I P Tokovenko, L P Malynovs'ka, L P Panchenko, L O Havrylko, A S Shalamaĭ, I V Aleksieieva
JournalMikrobiolohichnyĭ zhurnal (Kiev, Ukraine : 1993) (Mikrobiol Z) 1996 Sep-Oct Vol. 58 Issue 5 Pg. 80-5 ISSN: 1028-0987 [Print] UKRAINE
Vernacular TitleObhruntuvannia mozhlyvosti zastosuvannia monotsukriv i 6-azatsytydynu dlia eliminatsiï z urohenital'noho traktu liudyny molikutiv, iaki asotsiiuiut' z VIL/SNIDom.
PMID9044715 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Culture Media
  • Monosaccharides
  • Receptors, Cell Surface
  • 6-azacytidine
  • Azacitidine
  • AIDS-Related Opportunistic Infections (metabolism, microbiology)
  • Acholeplasma laidlawii (drug effects, growth & development, metabolism)
  • Anti-Bacterial Agents
  • Anti-Infective Agents (pharmacology)
  • Azacitidine (analogs & derivatives, pharmacology)
  • Binding, Competitive (drug effects)
  • Culture Media
  • HIV-1
  • Humans
  • Monosaccharides (metabolism, pharmacology)
  • Mycoplasma Infections (metabolism, microbiology)
  • Mycoplasma fermentans (drug effects, growth & development, metabolism)
  • Receptors, Cell Surface (drug effects, metabolism)
  • Urogenital System (metabolism, microbiology)

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