[Paraneoplastic superior vena cava thrombosis disclosing an ovarian tumor].

Abstract

We report the case of a patient who was admitted in hospital for evaluation of a superior vena cava thrombosis. The patient exhibited an activated protein C resistance due to an arginine-506 mutation in factor V. Thoracic CT-scan showed a non-compressive complete superior vena cava thrombosis. Other investigations revealed a pleural effusion associated with an ovarian tumor. Pathological data of pleural biopsies showed a papillar carcinoma. Ovarian neoplasia revealed by a paraneoplasic syndrome was diagnosed. Treatment associated cyclophosphamide and carboplatin with anti-K-vitamin was administrated, with a complete remission and disappearance of superior vena cava thrombosis at 27 months of evolution. At this date, we observed a local pelvis recurrence which was treated with paclitaxel associated with surgery.

• Authors: M Padovani, I Tillie-Leblond, P Vennin, G Demarcq, B Wallaert
• Journal: Revue des maladies respiratoires (Rev Mal Respir) Vol. 13 Issue 6 Pg. 598-600 (Dec 1996) ISSN: 0761-8425 [Print] France
• Vernacular Title: Thrombose cave supérieure paranéoplasique révélant une tumeur ovarienne.
• PMID: 9036506 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Antineoplastic Agents
• Antineoplastic Agents, Alkylating
• Protein C
• factor V Leiden
• Vitamin K
• Cyclophosphamide
• Factor V
• Carboplatin

Topics

• Anticoagulants (therapeutic use)
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Agents, Alkylating (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoma, Papillary (complications, drug therapy)
• Cyclophosphamide (administration & dosage)
• Factor V (genetics)
• Female
• Humans
• Middle Aged
• Mutation (genetics)
• Ovarian Neoplasms (complications, drug therapy)
• Paraneoplastic Syndromes (drug therapy, etiology)
• Pleural Effusion (etiology)
• Protein C (genetics)
• Protein C Deficiency
• Remission Induction
• Superior Vena Cava Syndrome (drug therapy, etiology)
• Vitamin K (antagonists & inhibitors)