[Value of cyclosporine in the treatment of the recurrence of nephrosis after renal transplantation].

Abstract

From May 1992 to December 1994, 14 children with end stage renal failure secondary to steroid-resistant idiopathic nephrotic syndrome received a cadaver kidney graft. Immediate recurrence of the nephrotic syndrome occurred in four patients. In the four patients, a complete remission was observed shortly after the start of intravenous cyclosporin; two children received in addition methylprednisolone pulses for secondary rejection. Two children were still protein-free 9 and 15 months after transplantation. In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. The fourth graft was lost at 3.5 month from irreversible rejection. The creatinine clearance of the 3 functioning grafts was respectively: 73, 76 and 92 ml/mn/1.73 m2 16, 10 and 15 months after transplantation. Intravenous cyclosporin started shortly after the recurrence, maintaining blood levels between 200 and 300 ng/ml, may induce a remission in recurrent nephrotic syndrome after renal transplantation in childhood.

• Authors: B Ranchin, M F Gagnadoux, M Broyer, A Lehnert, A Juresco, N Chérif, D Jan, D Droz, M C Gubler, P Niaudet
• Journal: Nephrologie (Nephrologie) Vol. 17 Issue 8 Pg. 441-5 ( 1996) ISSN: 0250-4960 [Print] Switzerland
• Vernacular Title: Intérêt de la ciclosporine dans le traitement des récidives de néphrose après transplantation rénale.
• PMID: 9036367 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cyclosporine

Topics

• Child, Preschool
• Cyclosporine (therapeutic use)
• Female
• Humans
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation
• Male
• Nephrotic Syndrome (drug therapy)
• Recurrence