[Aminostigmine-a novel drug against home poisoning].

Abstract

Aminostigmin, a novel reversible inhibitor of cholinesterase developed in Russia, has been tried in management of poisoning with cholinolytyics, antihistamine drugs, tricycle antidepressants and derivatives of 1,4-benzodiazepine. The treatment of 144 patients with aminostigmin and 20 patients with galantamin showed close to similar efficacy of these drugs. The scheme of aminostigmin administration is proposed warranting fast relief of cholinolytic syndrome in subjects poisoned with cholinolytics, antihistamine drugs and antidepressants. Benzodiazepines poisoning was unresponsive to aminostigmin. Rare side effects were caused by overdose. Aminostigmin is an effective antidote in cholinolytic poisoning.

• Authors: I I Bonitenko, G A Safronov, A E Sosiukin, V N Pershin, L S Shpilenia
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 74 Issue 8 Pg. 58-61 ( 1996) ISSN: 0023-2149 [Print] Russia (Federation)
• Vernacular Title: Primenenie novogo lekarstvennogo sredstva aminostigmina v terapii bytovykh otravlenii.
• PMID: 9036214 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• Carbamates
• Cholinesterase Inhibitors
• Pyridines
• Galantamine
• aminostigmine
• Pyridostigmine Bromide

Topics

• Adolescent
• Adult
• Antidotes (therapeutic use)
• Carbamates
• Cholinesterase Inhibitors (therapeutic use)
• Female
• Galantamine (therapeutic use)
• Humans
• Male
• Middle Aged
• Poisoning (drug therapy)
• Pyridines
• Pyridostigmine Bromide (analogs & derivatives)
• Treatment Outcome