Abstract | BACKGROUND: METHOD: In a prospective, randomized, controlled study over a period of 3 months, 40 patients with nonarteritic ischemic optic neuropathy ( NAION) were randomly assigned to either HELP or hemodilution therapy to determine the efficacy of these two treatments on visual acuity and fields. RESULTS: After transformation of the Snellen acuity into logMAR units the statistical analysis did not show a significant difference between the two groups (P = 0.48). An increase of the visual acuity by two or more lines was obtained in 9 patients (47.4%) of the HELP group, 10 (52.6%) remained stable and none got worse. In the hemodilution group, visual acuity increased in patients (33.4%), 9 (42.8%) remained stable and 5 (23.8%) experienced a decrease. The calculated mean sensitivity of visual fields at baseline improved statistically significantly (P < 0.01) in the HELP group from 6.83 +/- 4.52 dB to 8.27 +/- 4.89 dB, but did not change significantly in the hemodilution group (6.25 +/- 4.12 dB to 6.12 +/- 3.92 dB). CONCLUSION: The HELP system seems to be safe and more effective than hemodilution in improving the hemorheological and the functional situation in NAION and could be a promising regimen in the treatment of NAION.
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Authors | A Haas, M Walzl, F Jesenik, B Walzl, A Berghold, J Berglöff, B Feigl, J Faulborn |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 235
Issue 1
Pg. 14-9
(Jan 1997)
ISSN: 0721-832X [Print] Germany |
PMID | 9034837
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fibrinolytic Agents
- Lipoproteins, LDL
- Fibrinogen
- Heparin
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Topics |
- Aged
- Arteritis
(blood, physiopathology, therapy)
- Blood Viscosity
- Evoked Potentials, Visual
(physiology)
- Extracorporeal Circulation
- Female
- Fibrinogen
(metabolism)
- Fibrinolytic Agents
(administration & dosage)
- Fractional Precipitation
- Hemodilution
(methods)
- Heparin
(administration & dosage)
- Humans
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Optic Neuropathy, Ischemic
(blood, physiopathology, therapy)
- Prospective Studies
- Visual Acuity
- Visual Fields
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