Hb S/Hb Lepore with mild sickling symptoms: a hemoglobin variant with mostly delta-chain sequences ameliorates sickle-cell disease.

Abstract

Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a nonalpha-chain variant with a high proportion of delta chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A2 may be beneficial in sickle-cell disease.

• Authors: V F Fairbanks, D J McCormick, K S Kubik, W N Rezuke, D Black, M S Ochaney, D Schwartz
• Journal: American journal of hematology (Am J Hematol) Vol. 54 Issue 2 Pg. 164-5 (Feb 1997) ISSN: 0361-8609 [Print] United States
• PMID: 9034293 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobin, Sickle
• Hemoglobins
• Hemoglobins, Abnormal
• hemoglobin Lepore

Topics

• Adolescent
• Adult
• Anemia, Sickle Cell (blood, physiopathology)
• Female
• Genetic Variation
• Hemoglobin, Sickle (analysis)
• Hemoglobins (genetics)
• Hemoglobins, Abnormal (analysis)
• Humans
• Male