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Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome.

Abstract
A defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D5 receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for linkage to the dopamine D5 receptor gene using a microsatellite polymorphism located in the same cosmid clone. Using an autosomal dominant model with reduced penetrance, we were able to exclude linkage in four of the five families for the TS and chronic multiple tics (CMT) phenotype. Also, no evidence for linkage was found using nonparametric methods in all five families.
AuthorsC L Barr, K G Wigg, E Zovko, P Sandor, L C Tsui
JournalAmerican journal of medical genetics (Am J Med Genet) Vol. 74 Issue 1 Pg. 58-61 (Feb 21 1997) ISSN: 0148-7299 [Print] United States
PMID9034008 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DRD5 protein, human
  • Receptors, Dopamine D1
  • Receptors, Dopamine D5
Topics
  • Canada
  • Female
  • Genes, Dominant
  • Genetic Linkage
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Microsatellite Repeats
  • Pedigree
  • Phenotype
  • Polymorphism, Genetic
  • Receptors, Dopamine D1 (genetics)
  • Receptors, Dopamine D5
  • Software
  • Tic Disorders (genetics, metabolism)
  • Tourette Syndrome (genetics, metabolism)

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