Prevention of NSAID-gastropathy.

Abstract

The role is reviewed of gastric antisecretory and mucosal protective drugs in the prevention of NSAID-induced gastric and duodenal mucosal lesions. The results of the randomized, double-blind, controlled trials show that misoprostol is the only antiulcer drug proven to be effective in the prevention of NSAID-induced gastric and duodenal ulcers as well as for reducing serious upper gastrointestinal complications (perforation and/or haemorrhage). However, recent data suggest that even omeprazole and high dose of H2-receptor antagonists may have a role in the prevention of NSAID-induced gastric and duodenal ulcerations.

• Authors: S Ardizzone, G Bianchi Porro
• Journal: The Italian journal of gastroenterology (Ital J Gastroenterol) Vol. 28 Suppl 4 Pg. 33-6 (Dec 1996) ISSN: 0392-0623 [Print] Italy
• PMID: 9032581 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Histamine H2 Antagonists
• Sialoglycoproteins
• Misoprostol
• sulglicotide
• Omeprazole

Topics

• Adult
• Age Factors
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Anti-Ulcer Agents (therapeutic use)
• Duodenal Ulcer (chemically induced, prevention & control)
• Histamine H2 Antagonists (therapeutic use)
• Humans
• Misoprostol (therapeutic use)
• Omeprazole (therapeutic use)
• Peptic Ulcer Hemorrhage (prevention & control)
• Peptic Ulcer Perforation (prevention & control)
• Risk Factors
• Sialoglycoproteins (therapeutic use)
• Stomach Ulcer (chemically induced, prevention & control)