Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida.

Abstract

Nidulal (1), a novel inducer of differentiation of human HL-60 promyelocytic leukemia cells, was isolated from fermentations of the basidiomycete Nidula candida together with low amounts of niduloic acid (2). Both compounds are bisabolane sesquiterpenes. Their structures were elucidated by spectroscopic methods. In reporter gene assays nidulal (1) preferentially activated the transcription factor complex AP-1-mediated expression of secreted alkaline phosphatase in COS-7 cells. In addition nidulal (1) and niduloic acid (2) exhibited weak cytotoxic and antibiotic activities.

• Authors: G Erkel, U Becker, T Anke, O Sterner
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 49 Issue 12 Pg. 1189-95 (Dec 1996) ISSN: 0021-8820 [Print] England
• PMID: 9031663 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cyclohexanecarboxylic Acids
• Furans
• Spiro Compounds
• Transcription Factor AP-1
• nidulal
• niduloic acid
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (genetics)
• Animals
• Anti-Bacterial Agents (pharmacology)
• Apoptosis
• Basidiomycota (metabolism)
• COS Cells
• Cell Differentiation
• Cell Line
• Cyclohexanecarboxylic Acids (chemistry, metabolism, pharmacology)
• DNA Fragmentation
• Drug Evaluation, Preclinical
• Fungi (drug effects)
• Furans (chemistry, metabolism, pharmacology)
• HL-60 Cells
• Humans
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Molecular Structure
• Mutagenicity Tests
• Salmonella typhimurium (drug effects)
• Signal Transduction
• Spiro Compounds (chemistry, metabolism, pharmacology)
• Transcription Factor AP-1 (metabolism)
• Transcription, Genetic