Two cases of severe bronchiectasis successfully treated with a prolonged course of trimethoprim/sulfamethoxazole.

Abstract

Two patients with severe bronchiectasis, one patient without other disease and the other with hyper IgE syndrome, were successfully treated with long-term therapy with low doses of trimethoprim and sulfamethoxazole (TMP-SMZ). Recurrent respiratory infections with productive cough and high fever were resistant to various antibiotics and often disturbed the patients' activities in daily life. However, they showed marked improvement following TMP-SMZ therapy, which was started for methicillin-resistant Staphylococcus aureus (MRSA) infection. MRSA disappeared some months later, but Pseudomonas aeruginosa appeared again in the sputum. Both patients, however, have remained free from symptoms for over one year.

• Authors: T Honda, M Hayasaka, T Hachiya, K Kubo, T Katsuyama, A Nagata
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 35 Issue 12 Pg. 979-83 (Dec 1996) ISSN: 0918-2918 [Print] Japan
• PMID: 9030999 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage)
• Bronchiectasis (drug therapy)
• Female
• Humans
• Male
• Methicillin Resistance
• Middle Aged
• Pseudomonas Infections (drug therapy)
• Staphylococcal Infections (drug therapy)
• Staphylococcus aureus
• Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage)