Sonodynamically induced antitumor effect of gallium-porphyrin complex by focused ultrasound on experimental kidney tumor.

Abstract

The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.

• Authors: N Yumita, K Sasaki, S Umemura, A Yukawa, R Nishigaki
• Journal: Cancer letters (Cancer Lett) Vol. 112 Issue 1 Pg. 79-86 (Jan 15 1997) ISSN: 0304-3835 [Print] Ireland
• PMID: 9029172 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Porphyrins
• ATX 70

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Combined Modality Therapy
• Kidney
• Male
• Mice
• Mice, Inbred BALB C
• Neoplasm Transplantation
• Neoplasms (drug therapy, therapy)
• Porphyrins (therapeutic use)
• Ultrasonic Therapy (methods)