Abstract |
The antitumor effect of a gallium- porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.
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Authors | N Yumita, K Sasaki, S Umemura, A Yukawa, R Nishigaki |
Journal | Cancer letters
(Cancer Lett)
Vol. 112
Issue 1
Pg. 79-86
(Jan 15 1997)
ISSN: 0304-3835 [Print] Ireland |
PMID | 9029172
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Porphyrins
- ATX 70
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Combined Modality Therapy
- Kidney
- Male
- Mice
- Mice, Inbred BALB C
- Neoplasm Transplantation
- Neoplasms
(drug therapy, therapy)
- Porphyrins
(therapeutic use)
- Ultrasonic Therapy
(methods)
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