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Effects of erythromycin in chronic idiopathic intestinal pseudo-obstruction.

Abstract
The prokinetic effects of erythromycin, a macrolide antibiotic, on the gastrointestinal tract as a motilin receptor agonist and its potential value for the treatment of gastrointestinal motility disorders have recently attracted interest. The effects of erythromycin on the clinical symptoms and gastrointestinal motility of patients with chronic idiopathic pseudo-obstruction have not been investigated extensively. We presented a case of chronic idiopathic intestinal pseudo-obstruction, in a 67-year-old man in whom oral erythromycin (900 mg/day) dramatically improved postprandial abdominal distention, nausea, and vomiting. Other agents with prokinetic effects on intestinal motility, i.e., cisapride, domperidone, metoclopramide, and trimebutine maleate did not have a favorable effect. Gastric emptying, measured by the sulfamethizole method; and intestinal transit, evaluated using radio-opaque markers, were markedly improved by treatment with erythromycin. Our experience suggests that the prokinetic effects of erythromycin may be of therapeutic value in chronic idiopathic intestinal pseudo-obstruction.
AuthorsT Minami, H Nishibayashi, Y Shinomura, Y Matsuzawa
JournalJournal of gastroenterology (J Gastroenterol) Vol. 31 Issue 6 Pg. 855-9 (Dec 1996) ISSN: 0944-1174 [Print] Japan
PMID9027652 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Erythromycin
Topics
  • Administration, Oral
  • Aged
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Erythromycin (administration & dosage, therapeutic use)
  • Follow-Up Studies
  • Gastric Emptying (drug effects)
  • Gastrointestinal Transit (drug effects)
  • Humans
  • Intestinal Pseudo-Obstruction (diagnosis, drug therapy, physiopathology)
  • Male

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