[Changes in the activity of gamma-glutamyltransferase and cholinesterase in the blood of patients with opisthorchiasis at different phases of the disease].

Abstract

The plasma activity of gamma-glutamyl transferase (GGT) and cholinesterase (CE) was assayed in 79 patients with opisthorchiasis in its active and chronic periods, as well in different periods after anthelminthic therapy with biltricide and azinox. The mean values of CE activity did not significantly differ between the groups of the examinees. The probability of decreased CE synthesis in the residual period was significantly greater in the treatment of chronic than acute opisthorchiasis. The maximum activity of GGT was found in acute opisthorchiasis, its values were also significantly higher than the control ones and remained unchanged within a year after anthelminthic therapy. Possible causes of delayed normalization of enzymatic activity following the treatment of chronic versus acute opisthorchiasis are discussed in the paper.

• Authors: I V Bakshtanovskaia, T F Stepanova, A L Shonin, T L Grigor'eva
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1996 Oct-Dec Issue 4 Pg. 33-5 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Izmeneniia aktivnosti gamma-glutamiltransferzay i kholinésterazy v krovi bol'nykh opistorkhozom v razlichnykh fazakh zabolevaniia.
• PMID: 9026671 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiplatyhelmintic Agents
• azinox
• Praziquantel
• gamma-Glutamyltransferase
• Cholinesterases

Topics

• Acute Disease
• Animals
• Antiplatyhelmintic Agents (therapeutic use)
• Cholinesterases (blood)
• Chronic Disease
• Clinical Enzyme Tests
• Humans
• Opisthorchiasis (diagnosis, drug therapy)
• Praziquantel (analogs & derivatives, therapeutic use)
• Statistics, Nonparametric
• Time Factors
• gamma-Glutamyltransferase (blood)