Induction of epithelial neoplasms by local application of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxypropyl)amine.

Abstract

The local carcinogenic effect of N-nitrosobis(2-hydroxypropyl)amine (BHP) and N-nitrosobis(2-acetoxypropyl)amine (BAP) in Syrian golden hamsters was elucidated by weekly application to the cheek pouch, lip and vaginal epithelium. The tumor type and incidence in BHP- and BAP-treated hamsters, respectively, was as follows: trichoepitheliomas of the lip, 80 and 90%; cheek pouch papillomas, 10 and 0%, and vaginal papillomas, 80 and 70%. Other lesions were recorded in the perineum, rectum and external urethral ostium and could have been due to a local effect of these nitrosamines. In addition, internal organ tumors were observed with each compound and were possibly caused by absorption of the carcinogens.

• Authors: P Pour, J Althoff, D Nagel
• Journal: Cancer letters (Cancer Lett) Vol. 3 Issue 3-4 Pg. 109-13 (Sep 1977) ISSN: 0304-3835 [Print] Ireland
• PMID: 902248 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitrosamines
• diisopropanolnitrosamine
• N-nitrosobis(2-acetoxypropyl)amine

Topics

• Animals
• Cheek
• Cricetinae
• Female
• Lip Neoplasms (chemically induced)
• Mesocricetus
• Mouth Neoplasms (chemically induced)
• Neoplasms, Experimental (chemically induced)
• Nitrosamines (administration & dosage, toxicity)
• Papilloma (chemically induced)
• Skin Neoplasms (chemically induced)