Insulin-like growth factor binding protein-3 in breast cyst fluid: relationships with insulin-like growth factors I and II and transforming growth factor-beta 1 and 2.

Abstract

Women who have palpable breast cysts with intracystic Na/K > 3 may have a lower risk of developing breast cancer than those with intracystic Na/K < 3. In this study significantly higher concentrations of insulin-like growth factor-binding protein-3 (IGFBP-3), insulin-like growth factors I and II (IGF-I, IGF-II) and transforming growth factor-beta 2 (TGF-beta2) were found in the Na/K > 3 sub-group. No difference was found in transforming-growth factor-beta 1 (TGF-beta1) levels between the two sub-groups of breast cysts. A positive correlation was obtained for IGFBP-3 and TGF-beta1 in the Na/ K > 3 sub-group consistent with reports that TGF-beta1 may regulate the production of IGFBP-3. Equimolar amounts of total IGFs and IGFBP-3 in breast cyst fluid imply that most, if not all, of these IGFs are protein-bound. The significantly higher concentrations of TGF-beta2 in the Na/K > 3 sub-group may partly explain the lower risk of breast cancer in this group of women.

• Authors: L C Lai, H Erbas, K A Meadows, T W Lennard, J M Holly
• Journal: Cancer letters (Cancer Lett) Vol. 110 Issue 1-2 Pg. 207-12 (Dec 20 1996) ISSN: 0304-3835 [Print] Ireland
• PMID: 9018103 (Publication Type: Journal Article)

Chemical References

• Insulin-Like Growth Factor Binding Protein 3
• Transforming Growth Factor beta
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II
• Sodium
• Potassium

Topics

• Exudates and Transudates (chemistry)
• Female
• Fibrocystic Breast Disease (chemistry, classification)
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (analysis)
• Insulin-Like Growth Factor I (analysis)
• Insulin-Like Growth Factor II (analysis)
• Potassium (analysis)
• Sodium (analysis)
• Transforming Growth Factor beta (analysis)