Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy.

Abstract

The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.

• Authors: B Donnerstag, G Ohlenschlager, J Cinatl, M Amrani, D Hofmann, S Flindt, G Treusch, L Träger
• Journal: Cancer letters (Cancer Lett) Vol. 110 Issue 1-2 Pg. 63-70 (Dec 20 1996) ISSN: 0304-3835 [Print] Ireland
• PMID: 9018082 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm
• S-acetylglutathione
• Glutathione

Topics

• Apoptosis
• Cell Division (drug effects)
• Cell Survival (drug effects)
• DNA Fragmentation
• DNA, Neoplasm (analysis, drug effects)
• Drug Screening Assays, Antitumor
• Electrophoresis, Agar Gel
• Glutathione (analogs & derivatives, pharmacology)
• Humans
• Tumor Cells, Cultured (drug effects, pathology)