Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.

Abstract

1 Lincomycin (600 mg) was given 6 h preoperatively by intramuscular injection, as an intravenous infusion over 30 min and for 72 h postoperatively in twelve patients having total hip replacement. 2 The plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin were almost always above the M.I.C. of lincomycin against penicillinase producing Staphylococcus aureus. 3 There was a good correlation between the estimated concentrations of lincomycin in bone by the grinding and agitation methods of analysis. 4 Two patients developed pseudomembranous colitis after parenteral lincomycin.

• Authors: R L Parsons, J P Beavis, G A Hossack, G M Paddock
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 4 Issue 4 Pg. 433-7 (Aug 1977) ISSN: 0306-5251 [Print] England
• PMID: 901734 (Publication Type: Journal Article)

Chemical References

• Lincomycin

Topics

• Adult
• Aged
• Body Fluids (metabolism)
• Bone and Bones (metabolism)
• Female
• Hip Joint (metabolism, surgery)
• Humans
• Lincomycin (blood, metabolism, therapeutic use)
• Male
• Middle Aged
• Surgical Wound Infection (prevention & control)
• Synovial Fluid (metabolism)
• Time Factors