Effectiveness of shakuyaku-kanzo-to in neuroleptic-induced hyperprolactinemia: a preliminary report.

Abstract

We investigated the efficacy of Shakuyaku-kanzo-to (TJ-68) in neuroleptic-induced hyperprolactinemia in 11 treated schizophrenic patients. The mean plasma prolactin level decreased significantly from 28.9 +/- 14.5 ng/mL at baseline to 22.0 +/- 15.2 ng/mL at 4 weeks. Potassium levels did not change significantly. Neither the exacerbation of psychosis nor other adverse effects occurred.

• Authors: K Yamada, S Kanba, T Murata, M Fukuzawa, B Terashi, G Yagi, M Asai
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 50 Issue 6 Pg. 341-2 (Dec 1996) ISSN: 1323-1316 [Print] Australia
• PMID: 9014235 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antipsychotic Agents
• Drug Combinations
• Drugs, Chinese Herbal
• shakuyaku-kanzoh-toh
• Prolactin

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antipsychotic Agents (adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Combinations
• Drugs, Chinese Herbal (therapeutic use)
• Glycyrrhiza
• Humans
• Hyperprolactinemia (chemically induced, therapy)
• Male
• Middle Aged
• Paeonia
• Prolactin (blood)
• Schizophrenia (drug therapy)