HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Serum leptin levels following hypothalamic surgery.

Abstract
To study a potential alteration of hypothalamic centers involved in the negative feedback action of leptin on body weight, serum leptin levels were measured in relation to BMI in 18 patients following surgery for a hypothalamic craniopharyngioma (Ctx), and were compared to levels found in 21 patients operated for a pituitary adenoma (Ptx) or in healthy control subjects. All subjects with Ptx received rhGH replacement therapy (0.5 to 2 IU/m2/d), and serum leptin levels were followed in 3 months intervals over 24 months. Serum leptin levels in patients with Ptx were comparable to controls, whereas 7 of the 18 patients with Ctx had higher than expected concentrations for their BMI. GH treatment in Ptx subjects did not alter serum leptin levels. In 5 Ctx patients where preoperative samples were available, weight gain in parallel to an increase in serum leptin levels was observed but only minimal changes in 4 others. Our data support the role of leptin as an important marker of body weight. The rapid increase in serum leptin levels observed in some Ctx subjects suggests that early postoperative measurement of serum leptin levels may help to identify patients at risk of weight gain following hypothalamic destruction.
AuthorsG Brabant, R Horn, B Mayr, A von zur Mühlen, J Honegger, M Buchfelder
JournalHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et meĢtabolisme (Horm Metab Res) Vol. 28 Issue 12 Pg. 728-31 (Dec 1996) ISSN: 0018-5043 [Print] GERMANY
PMID9013752 (Publication Type: Journal Article)
Chemical References
  • Leptin
  • Proteins
Topics
  • Adenoma (blood, surgery)
  • Adolescent
  • Adult
  • Body Mass Index
  • Child
  • Child, Preschool
  • Craniopharyngioma (blood, surgery)
  • Female
  • Humans
  • Hypothalamic Neoplasms (blood, surgery)
  • Leptin
  • Male
  • Middle Aged
  • Pituitary Neoplasms (blood, surgery)
  • Proteins (metabolism)
  • Sex Characteristics
  • Weight Gain

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: