Abstract | CONCLUSION: BACKGROUND: Conflicting results have been obtained from studies designed to determine the role of CCK in the initial stages of pancreatitis. METHODS: RESULTS: Infusion of sodium taurocholate (50 mg/kg) into the pancreaticobiliary duct caused severe pancreatitis with marked hyperamylasemia and reduction of tissue enzyme content at 12 h postinfusion. Pretreatment with L-364,718, but not with camostat, caused significant improvement in signs of experimental pancreatitis based on tissue enzyme content and morphology. Compared with untreated pancreatitis, there was relatively well-preserved lobular architecture, less edema, less infiltration of inflammatory cells, and more zymogen granules after L-364,718 pretreatment. Moreover, the reduction of enzyme content owing to pancreatitis was ameliorated by L-364,718 pretreatment.
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Authors | K H Kim, M G Lee, D G Kim |
Journal | International journal of pancreatology : official journal of the International Association of Pancreatology
(Int J Pancreatol)
Vol. 20
Issue 3
Pg. 205-11
(Dec 1996)
ISSN: 0169-4197 [Print] United States |
PMID | 9013282
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzodiazepinones
- Cholagogues and Choleretics
- Esters
- Guanidines
- Hormone Antagonists
- Receptors, Cholecystokinin
- Trypsin Inhibitors
- camostat
- Gabexate
- Taurocholic Acid
- Amylases
- Devazepide
- Sincalide
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Topics |
- Amylases
(blood)
- Animals
- Benzodiazepinones
(pharmacology)
- Cholagogues and Choleretics
(pharmacology)
- Devazepide
- Esters
- Gabexate
(analogs & derivatives)
- Guanidines
(pharmacology)
- Histocytochemistry
- Hormone Antagonists
(pharmacology)
- Male
- Pancreas
(drug effects, pathology)
- Pancreatitis
(blood, chemically induced, pathology, prevention & control)
- Rats
- Rats, Sprague-Dawley
- Receptors, Cholecystokinin
(antagonists & inhibitors)
- Sincalide
(antagonists & inhibitors)
- Taurocholic Acid
- Trypsin Inhibitors
(pharmacology)
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