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[Usefulness of adenosine deaminase determination in cerebrospinal fluid for the diagnosis of meningeal tuberculosis: 4 years experience at a public hospital].

Abstract
The aim of this work was to study the usefulness of CSF adenosine deaminase determination in the diagnosis of tuberculous meningitis and determine if the proposed cutoff value of 7.1 i.u./ml had the better sensitivity and specificity. We retrospectively studied 148 patients, 12 with tuberculous meningitis and 136 with other central nervous system diseases. Adenosine deaminase values ranged from 3.6 to 31.2 i.u./ml in patients with tuberculous meningitis and from 0.1 to 312 i.u./ml in controls. The best sensitivity/specificity ratio (83.3 and 85.3% respectively) was obtained using a cutoff value of 6.5 i.u./ml. It is concluded that CSF adenosine deaminase values are useful in the diagnosis of tuberculous meningitis and that the cutoff value should be lowered to 6.5 i.u./ml to improve its diagnostic yield.
AuthorsM Baró, L Acevedo, M E Lagos
JournalRevista medica de Chile (Rev Med Chil) Vol. 124 Issue 3 Pg. 319-26 (Mar 1996) ISSN: 0034-9887 [Print] Chile
Vernacular TitleUtilidad de la determinación de adenosina deaminasa en líquido cefalorraquídeo para el diagnóstico de tuberculosis meníngea. Experiencia de 4 años en un hospital de Provincia.
PMID9008944 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Adenosine Deaminase
Topics
  • Adenosine Deaminase (cerebrospinal fluid)
  • Adolescent
  • Adult
  • Child, Preschool
  • Evaluation Studies as Topic
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tuberculosis, Meningeal (cerebrospinal fluid, diagnosis)

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