[Primary hyperparathyroidism--diagnostic problems].

Abstract

Parathyroid imaging with 99m Tc-MIBI, introduced at the beginning of the 90's seems to be a promising method for parathyroid adenomas localization. The aim of the study was to assess the efficacy of parathyroid imaging with 99m Tc-MIBI for preoperative localization of parathyroid adenomas and to compare that method with the high-resolution ultrasonography. Thirteen patients with primary hyperparathyroidism of duration from 2 to 25 years were included in the study. The presence of parathyroid adenomas was confirmed by histopathology in all patients. The sensitivity for scintigraphy and ultrasonography was 92.8% and 78.5%, the number of false positive results was 0 and 2 and false negative-0 and 1, respectively. Parathyroid imaging with 99m Tc-MIBI is a useful method for parathyroid adenomas localization, and in contrast to ultrasonography its sensitivity does not decrease if a parathyroid adenoma is located ectopically. Nevertheless, because of the greater accessibility, lower costs and its simplicity ultrasonography should be used as a screening modality for parathyroid adenoma localization.

• Authors: W Horst-Sikorska, D Baszko-Błaszczyk, M Drews, R Junik, L Pietz, M Gembicki, J Kosowicz
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 95 Issue 6 Pg. 534-41 (Jun 1996) Poland
• Vernacular Title: Pierwotna nadczynność przytarczyc--problemy diagnostyczne.
• PMID: 9005422 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Technetium Tc 99m Sestamibi

Topics

• Adolescent
• Adult
• Aged
• Female
• Humans
• Hyperparathyroidism (diagnostic imaging, prevention & control)
• Male
• Mass Screening (methods)
• Middle Aged
• Predictive Value of Tests
• Radionuclide Imaging
• Sensitivity and Specificity
• Technetium Tc 99m Sestamibi
• Ultrasonography