HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Antiproliferative therapy with 5-fluorouracil in erbium:YAG laser sclerostomy ab externo].

AbstractBACKGROUND:
Erbium laser sclerostomy (ELS) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery. To date, the success rate of this method is lower than that of trabeculectomy or goniotrepanation. The chief cause of therapy failure is postoperative episcleral scarring of the bleb. It was the aim of the present study to decrease the occlusion rate of this complication.
PATIENTS AND METHODS:
41 eyes were treated with subconjunctival injections of 5-fluorouracil perioperatively to an intended total dose of 40 mg to prevent episcleral scarring. At the same time, bigger probe diameters were used (550 microns and 700 microns instead of 300 microns).
RESULTS:
After 3 months, the proportion of patients with regulated intraocular pressure after using bigger probe diameters combined with anti-proliferative therapy was significantly higher (550 microns fiber +5-FU: 73%; 700 microns fiber +5-FU: 71%) than for a 300 microns fiber without 5-FU (38%). Average intraocular pressure in successful cases was 11.6 +/- 4.2 mmHg in the 550 microns fiber +5-FU group and 12.3 +/- 4.0 mmHg in the 700 microns fiber +5-FU group.
CONCLUSION:
The short-term results of erbium laser sclerostomy as a minimally invasive technique can be improved by using increasing laser fiber diameters and by perioperative injections of 5-FU to prevent episcleral fibrosis.
AuthorsJ M Schmidbauer, H Höh, T Jähnig, I Daberkow
JournalDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 93 Issue 5 Pg. 569-75 (Oct 1996) ISSN: 0941-293X [Print] Germany
Vernacular TitleAntiproliferative Therapie mit 5-Fluorouracil bei Erbium:YAG-Laser-Sklerostomie ab externo.
PMID9004883 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antimetabolites
  • Fluorouracil
Topics
  • Antimetabolites (administration & dosage)
  • Cell Division (drug effects)
  • Cicatrix (prevention & control)
  • Combined Modality Therapy
  • Female
  • Fluorouracil (administration & dosage)
  • Glaucoma (surgery)
  • Humans
  • Injections
  • Intraocular Pressure (drug effects)
  • Laser Therapy
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures
  • Postoperative Complications (prevention & control)
  • Sclerostomy
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: