HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Therapy with antibody against leukocyte integrin VLA-4 (CD49d) is effective and safe in virus-facilitated experimental allergic encephalomyelitis.

Abstract
Experimental allergic encephalomyelitis (EAE) is facilitated in resistant BALB/c mice by intraperitoneal infection with an avirulent Semliki Forest virus (SFV-A7). Viral infection increases the incidence of EAE from 15-30% to 60-90% and speeds up appearance of paralysis from 24 to 14 days. In this paper, we describe treatment of virus-facilitated EAE with monoclonal antibodies (mAbs) against leukocyte and/or endothelial cell adhesion molecules. Therapy with mAb against ICAM-1 (intercellular adhesion molecule-1) had a modest effect, but caused hemorrhagic brain and spinal cord lesions. Therapy with mAb against Mac-1 (alpha M beta 2-integrin) was well tolerated but had no effect. Therapy with mAb against VLA-4 (alpha 4 beta 1-integrin) was safe, diminished both clinical and histopathological signs of EAE, decreased induction of VCAM-1 (vascular cell adhesion molecule-1) on brain vessels and diminished infiltration of VLA-4+ cells into the brain. The amount of viral antigen in the brain was not altered. We conclude that facilitation of leukocyte entry into the brain is a major mechanism for viral facilitation of EAE in the BALB/c mouse, and that facilitation can be inhibited by anti-adhesion therapy. This may have implications for treatment of relapses triggered by viral infections in multiple sclerosis.
AuthorsM Soilu-Hänninen, M Röyttä, A Salmi, R Salonen
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 72 Issue 1 Pg. 95-105 (Jan 1997) ISSN: 0165-5728 [Print] NETHERLANDS
PMID9003249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, CD29
  • Antigens, Viral
  • Integrin alpha4beta1
  • Integrins
  • Macrophage-1 Antigen
  • Receptors, Lymphocyte Homing
  • Intercellular Adhesion Molecule-1
Topics
  • Animals
  • Antibodies, Monoclonal (pharmacology)
  • Antigens, CD29 (immunology)
  • Antigens, Viral (immunology)
  • Encephalomyelitis, Autoimmune, Experimental (immunology, therapy, virology)
  • Immunohistochemistry
  • Immunotherapy
  • Integrin alpha4beta1
  • Integrins (immunology)
  • Intercellular Adhesion Molecule-1 (immunology)
  • Macrophage-1 Antigen (chemistry, immunology)
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Lymphocyte Homing (immunology)
  • Semliki forest virus (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: