Abstract |
Glucosamine and its derivatives, such as glucosamine sulfate and N-acetyl-D-glucosamine (NAG), have been shown to be effective in the treatment of patients with osteoarthritis. Unfortunately, the half-life of glucosamine in the blood is relatively short; therefore, a sustained-release form of the compound would be highly desirable. The purpose of this pilot study was to determine whether the polymeric form of NAG (POLY-Nag) could provide a longer-lasting oral source of NAG. Ten healthy subjects each ingested 1 g/d of either NAG or POLY-Nag for 3 days. After a 4-day washout period, each subject was crossed over to receive the other compound for 3 days. Serum samples were collected and analyzed using high-performance liquid chromatography. Results show that orally ingested NAG and POLY-Nag are absorbed, resulting in increased serum levels of NAG, and POLY-Nag appears to be at least as effective as NAG. Serum levels of NAG had decreased by 48 hours after cessation of ingestion of NAG or POLY-Nag but were still above baseline levels. Increases in serum glucosamine levels indicate that NAG and POLY-Nag are converted to glucosamine in vivo. In conclusion, POLY-Nag may provide a source of serum glucosamine for treatment of patients with osteoarthritis. Longer and more rigorous pharmaco-kinetic and clinical studies need to be done.
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Authors | J M Talent, R W Gracy |
Journal | Clinical therapeutics
(Clin Ther)
1996 Nov-Dec
Vol. 18
Issue 6
Pg. 1184-90
ISSN: 0149-2918 [Print] United States |
PMID | 9001835
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Polymers
- Glucosamine
- Acetylglucosamine
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Topics |
- Absorption
- Acetylglucosamine
(pharmacokinetics, therapeutic use)
- Administration, Oral
- Adult
- Chromatography, High Pressure Liquid
- Cross-Over Studies
- Female
- Follow-Up Studies
- Glucosamine
(pharmacokinetics, therapeutic use)
- Half-Life
- Humans
- Male
- Middle Aged
- Osteoarthritis
(blood, drug therapy)
- Pilot Projects
- Polymers
(pharmacokinetics, therapeutic use)
- Reference Values
- Treatment Outcome
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