Tonkinelin: a novel annonaceous acetogenin from Uvaria tonkinensis.

Abstract

Further studies on the root bark of Uvaria tonkinensis Finet et Gagnep. (Annonacease) led to the isolation of a new Annonaceous acetogenin, tonkinelin (1). The structure of 1 was elucidated on the basis of spectral data and chemical evidence. This compound represents an unusual type of C37 Annonaceous acetogenin, having neither tetrahydrofuran (THF) nor epoxide rings and possessing only a vicinal diol in the hydrocarbon chain. Preliminary pharmacological tests showed that tonkinelin (1) inhibits human leukemia (HL-60) and human colon adenocarcinoma (HCT-8) cell lines in vitro.

• Authors: Y Chen, D Q Yu
• Journal: Planta medica (Planta Med) Vol. 62 Issue 6 Pg. 512-4 (Dec 1996) ISSN: 0032-0943 [Print] Germany
• PMID: 9000883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Furans
• Lactones
• tonkinelin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Drugs, Chinese Herbal
• Furans (chemistry, isolation & purification, pharmacology)
• Humans
• Lactones (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured