Great particles [32P]chromic phosphate for treatment of solid tumors.

Abstract

With the purpose of studying the effectivity of an intratumoral single dose of chromic [32P] phosphate with great particles for the treatment of solid tumors, studies of bioelimination, biodistribution and therapeutic action were carried out. Only for comparative purposes, similar studies were undertaken using a solution of sodium -32P- orthophosphate-gelatine. The results show that when sodium [32P] orthophosphate-gelatine is used, the percentage of total elimination is (85.90 +/- 8.70)% with a higher percentage in urine (64.50 +/- 13.70)% than in faeces (21.40 +/- 4.50)%. In biodistribution studies, the greater percentage is found in bone (15.54 +/- 2.21)% while only a (2.51 +/- 0.39)% remains in the tumor. When great particles chromic [32P]phosphate was intratumorally injected, we determined that the total elimination is equal (36.28 +/- 6.27)%, finding a higher amount in faeces (29.44 +/- 5.26)% than in urine (6.84 +/- 2.21)%. Biodistribution studies demonstrated that (49.82 +/- 5.41)% remains in the tumor and (9.63 +/- 4.89)% of the injected activity is found in the liver. On the other hand, when therapeutic action was evaluated, we observed that the percentage of tumor regression (P.T.R.) is 52.0% for the tumors injected with chromic [32P]phosphate and 0.0% for those injected with sodium [32P]orthophosphate-gelatine. These results show that the great particles colloid of chromic [32P]phosphate is not safe enough for the treatment of solid tumors, since it is mobilized from the injection point, delivering a high dose to the whole organism.

• Authors: M B Zubillaga, J R Boccio, J O Nicolini, R Ughetti, E Lanari, R A Caro
• Journal: Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia (Acta Physiol Pharmacol Ther Latinoam) Vol. 46 Issue 2 Pg. 103-10 ( 1996) ISSN: 0327-6309 [Print] Argentina
• PMID: 8998364 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromium Compounds
• Phosphates
• chromic phosphate
• sodium phosphate

Topics

• Adenocarcinoma (radiotherapy)
• Animals
• Chromium Compounds (administration & dosage, pharmacokinetics, therapeutic use)
• Feces (chemistry)
• Female
• Injections
• Mammary Neoplasms, Experimental (radiotherapy)
• Phosphates (administration & dosage, pharmacokinetics, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Remission Induction
• Treatment Outcome
• Urine (chemistry)