Abstract |
We investigated the effects of the adenosine type-1 receptor antagonist FK-838 on salt-induced hypertension in Dahl-Sea salt-sensitive (Dahl S) rats. Dahl S rats fed a high- salt (4% NaCl) diet for 4 weeks were treated with FK-838 or hydrochlorothiazide for 4 weeks and alterations in kidney function and morphologic changes were assessed. FK-838 attenuated the development of hypertension in Dahl S rats, and caused a decrease in aortic weight in a dose dependent fashion. The adenosine antagonist did not produce any detectable metabolic disturbance. The blood pressure reduction by FK-838 was associated with attenuation of glomerular and arterial injury in the kidney. The renal protective effect of FK-838 treatment was associated with a reduction of plasma renin activity and plasma aldosterone concentration. In contrast, the thiazide diuretic, which produced almost the same blood pressure reduction as FK-838, did not attenuate renal damage. These data indicate that adenosine A1 receptor antagonism reduces salt-induced hypertension and the consequent renal injuries.
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Authors | Y Uehara, A Numabe, N Hirawa, Y Kawabata, H Nagoshi, H Kaneko, T Gomi, A Goto, T Toyo-oka, M Omata |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 8
Issue 12 Pt 1
Pg. 1189-99
(Dec 1995)
ISSN: 0895-7061 [Print] United States |
PMID | 8998253
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Eicosanoids
- Purinergic P1 Receptor Antagonists
- Pyrazoles
- Pyridines
- Hydrochlorothiazide
- FK 838
- Sodium Chloride
- Creatinine
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Topics |
- Animals
- Antihypertensive Agents
(pharmacokinetics, therapeutic use)
- Blood Pressure
(drug effects, physiology)
- Body Weight
(drug effects)
- Creatinine
(urine)
- Eicosanoids
(urine)
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(chemically induced, drug therapy, genetics)
- Kidney
(metabolism, pathology)
- Kidney Function Tests
- Organ Size
(drug effects)
- Purinergic P1 Receptor Antagonists
- Pyrazoles
(pharmacokinetics, therapeutic use)
- Pyridines
(pharmacokinetics, therapeutic use)
- Rats
- Rats, Inbred Strains
- Sodium Chloride
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