Abstract | UNLABELLED: METHODS: RESULTS: Approximately 95% of both benign and malignant primary brain tumors were demonstrated by 99mTc(V)-DMSA SPECT images. False negative was noted in three cases. The early uptake ratios were closely related to the tumor vascularity but had no statistically significant difference in the tumor histology or histologic malignancy. The delayed uptake ratio, retention ratio and retention index were higher in the malignant tumors than the benign tumors. CONCLUSION: Technetium-99m(V)-DMSA washout from the tumor was highly dependent upon its histology and histologic malignancy. The delayed uptake ratio considerably reflected tumor histology and differentiated benign tumors from malignant tumors. The retention ratio and retention index significantly reflected tumor histology and histologic grade of primary brain tumors and clearly distinguished between benign and malignant tumors with statistically significant difference (p < 0.05). These results could suggest the clinical utility of 99mTc(V)-DMSA in imaging primary brain tumors and differentiating their histological malignancy grade noninvasively.
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Authors | T Hirano, H Otake, T Shibasaki, M Tamura, K Endo |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 38
Issue 1
Pg. 20-6
(Jan 1997)
ISSN: 0161-5505 [Print] United States |
PMID | 8998143
(Publication Type: Journal Article)
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Chemical References |
- Organotechnetium Compounds
- Technetium Tc 99m Dimercaptosuccinic Acid
- Succimer
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Topics |
- Adolescent
- Adult
- Aged
- Astrocytoma
(diagnostic imaging, metabolism)
- Brain Neoplasms
(diagnostic imaging, metabolism)
- Child
- Female
- Glioblastoma
(diagnostic imaging, metabolism)
- Glioma
(diagnostic imaging, metabolism)
- Humans
- Male
- Meningeal Neoplasms
(diagnostic imaging, metabolism)
- Meningioma
(diagnostic imaging, metabolism)
- Middle Aged
- Neurilemmoma
(diagnostic imaging, metabolism)
- Oligodendroglioma
(diagnostic imaging, metabolism)
- Organotechnetium Compounds
(pharmacokinetics)
- Radionuclide Imaging
- Succimer
(pharmacokinetics)
- Technetium Tc 99m Dimercaptosuccinic Acid
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