Immunohistochemical detection of c-erbB-2 oncoprotein in patients with breast cancer.

Abstract

Using a polyclonal antibody against the c-erbB-2 gene product, an immunohistochemical study on the expression of c-erbB-2 oncoprotein was performed in routine formalin-fixed, paraffin-embedded tissue sections from 119 patients with primary breast cancer. Overexpression of c-erbB-2 protein was detected in 35 cases (29%). There was a strongly negative association between c-erbB-2 protein overexpression and estrogen receptor status (p < 0.001). Expression of c-erbB-2 protein was found to be related to clinical stage and tumor size (p < 0.05) but not to the number of involved nodes or age of patients at diagnosis. In addition, this study demonstrated that the c-erbB-2 protein over-expression was an effective independent prognostic indicator in patients with breast cancer.

• Authors: S Chariyalertsak, S Chariyalertsak, A Cheirsilpa, K Sugano, H Ohkura
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 79 Issue 11 Pg. 715-21 (Nov 1996) ISSN: 0125-2208 [Print] Thailand
• PMID: 8997010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Receptor, ErbB-2

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (chemistry, drug therapy, pathology)
• Female
• Follow-Up Studies
• Humans
• Immunohistochemistry (methods)
• Middle Aged
• Receptor, ErbB-2 (analysis)
• Retrospective Studies