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Sulthiame-associated mild compensated metabolic acidosis.

Abstract
Sulthiame is effectively used in the treatment of benign and symptomatic focal epilepsy in children. Hyperventilation as a symptom is a well known adverse effect of the drug. Alterations of the acid-base equilibrium have been described for the drug, however, very infrequently only in adults without a detailed evaluation of the disorders status. The case presented here demonstrates a mild compensated metabolic acidosis in a child which, for the first time, is described using the methods of complete blood gas and electrolytes analysis.
AuthorsU Tröger, C Fritzsch, J Darius, J Gedschold, F P Meyer
JournalInternational journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 34 Issue 12 Pg. 542-5 (Dec 1996) ISSN: 0946-1965 [Print] Germany
PMID8996849 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticonvulsants
  • Thiazines
  • sulthiame
Topics
  • Acidosis (blood, chemically induced)
  • Anticonvulsants (adverse effects)
  • Blood Gas Analysis
  • Child, Preschool
  • Epilepsy (blood, drug therapy)
  • Humans
  • Male
  • Thiazines (adverse effects)

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