Antibacterial activity of TOC-50, a new parenteral cephalosporin against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae.

Abstract

TOC-50, a new parenteral cephalosporin, was assessed for antibacterial activity in vitro and in vivo. In vitro, the activity of TOC-50 was greater than ampicillin, erythromycin and gentamycin, and was equal to that of imipenem. The MICs of TOC-50 for 90% of the clinical isolates tested (MIC90 values) were 0.0125 microgram/ml for penicillin-susceptible Streptococcus pneumoniae, 0.2 microgram/ml for intermediately penicillin-resistant S. pneumoniae, and 0.39 microgram/ml for fully penicillin-resistant S. pneumoniae. In murine systemic-infection models, TOC-50 had a potent protective activity against penicillin-susceptible of fully penicillin-resistant S. pneumoniae. Its protective activity was stronger than that of imipenem.

• Authors: S Nomura, H Hanaki, T Furukawa, N Unemi
• Journal: Chemotherapy (Chemotherapy) 1997 Jan-Feb Vol. 43 Issue 1 Pg. 1-5 ISSN: 0009-3157 [Print] Switzerland
• PMID: 8996734 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cephalosporins
• Penicillins
• TOC 50
• Thienamycins
• Imipenem
• Penicillin G

Topics

• Animals
• Cephalosporins (pharmacology)
• Imipenem (pharmacology)
• Japan
• Male
• Mice
• Microbial Sensitivity Tests
• Penicillin G (pharmacology)
• Penicillin Resistance (genetics)
• Penicillins (pharmacology)
• Streptococcal Infections (drug therapy)
• Streptococcus pneumoniae (drug effects, genetics)
• Thienamycins (pharmacology)