Abstract |
Recurrent ocular herpes is an insoluble problem for the clinician. As cellular immunity plays an important role in controlling herpes relapses, and other studies have shown the efficacy of HSV-specific transfer factor (TF) for the treatment of herpes patients, an open clinical trial was undertaken in 134 patients (71 keratitis, 29 kerato- uveitis, 34 uveitis) suffering from recurrent ocular herpetic infections. The mean duration of the treatment was 358 days, and the entire follow-up period 189,121 before, and 64,062 days after TF treatment. The cell-mediated immune response to the viral antigens, evaluated by the lymphocyte stimulation test (LST) and the leucocyte migration test (LMT) (P < 0.001), was significantly increased by the TF treatment. The total number of relapses was decreased significantly during/after TF treatment, dropping from 832 before, to 89 after treatment, whereas the cumulative relapse index (RI) dropped, during the same period, from 13.2 to 4.17 (P < 0.0001). No side effects were observed. It is concluded that patients with relapsing ocular herpes can benefit from treatment with HSV-specific TF.
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Authors | R Meduri, E Campos, L Scorolli, C De Vinci, G Pizza, D Viza |
Journal | Biotherapy (Dordrecht, Netherlands)
(Biotherapy)
Vol. 9
Issue 1-3
Pg. 61-6
( 1996)
ISSN: 0921-299X [Print] Netherlands |
PMID | 8993759
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antibodies, Viral
- Antiviral Agents
- Transfer Factor
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibodies, Viral
(blood)
- Antiviral Agents
(immunology, therapeutic use)
- Cattle
- Child
- Child, Preschool
- Female
- Humans
- Immunity, Cellular
(drug effects, immunology)
- Keratitis, Herpetic
(immunology, therapy)
- Male
- Middle Aged
- Sensitivity and Specificity
- Simplexvirus
(immunology)
- Transfer Factor
(immunology, therapeutic use)
- Uveitis
(immunology, therapy)
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